Existen diversos estudios serios que avalan las características de los compuestos de la Synadenium Grantii, entre ellos el Phorbol. Invitamos a nuestros pacientes y lectores a visitar los sitios que señalamos a continuación:

• Antitumoural effect of Synadenium grantii Hook f.(Euphorbiaceae) latex

• TL de Oliveira, ACM Munhoz, BM Lemes… – Journal of …, 2013 – Elsevie

• Abstract Ethnopharmacological relevance Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. Aim of study Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell line.

• Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester A Campos, DB Vendramini-Costa… – … journal of toxicology, 2016 – journals.sagepub.com

• Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester. Adriana Campos, Débora Barbosa Vendramini-Costa, Giovanna Barbarini Longato, Tailyn Zermiani, Ana Lúcia Tasca Gois Ruiz, João Ernesto de Carvalho

• Isolation and characterization of proteolytic enzymes from the latex of Synadenium grantii Hook,’f’, M Menon, PJ Vithayathil, SM Raju, CS Ramadoss – Plant Science, 2002 – Elsevier

• Two fractions showing proteolytic enzymes have been obtained from the latex of Synadenium grantii Hook,’f’, using gel-filtration and anion-exchange chromatographic techniques. Both these proteases have the same molecular mass of 76±2 kDa each.

• Abstract Ethnopharmacological relevance Synadenium grantii Hook f. has traditionally been used to treat various neoplastic diseases in southern Brazil. Aim of study Evaluation of the antitumoural potential of Synadenium grantii latex against B16F10 melanoma cell.

• Two new phorbol-type diterpene esters have been isolated from the chloroform extract of the leaves of Synadenium grantii Hook F. and identified as 3, 4, 12, 13-tetraacetylphorbol-20- phenylacetate and 4-deoxyphorbol-12, 13-ditiglate for which the trivial names Synagrantol

• EXPERIMENTAL Plant Material-Synadenium grantii Hook. f. (Euphorbiaceae), propagated from a cutting’, was used as the source of latex2. Extraction and Fractionation-Dried latex (19.9 g) was extracted at room temperature with six 100-ml portions of acetone

Si te interesa saber más sobre la Artemisa Annua, aquí tienes algunos estudios y artículos destacados:

• Unexpected mechanism of colitis amelioration by artesunate, a natural product from Artemisia annua L

• Artemisinin Induces Apoptosis in Human Cancer Cells

• Polyphenols from Artemisia annua L Inhibit Adhesion and EMT of Highly Metastatic Breast Cancer Cells MDA-MB-231

• Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2

• Influence of Artemisia annua extract derivatives on proliferation, apoptosis and metastasis of osteosarcoma cells

• Artemisinin reduces cell proliferation and induces apoptosis in neuroblastoma

• Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway

• Novel artemisinin derivatives with potential usefulness against liver/colon cancer and viral hepatitis

• Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin

• In vitro and in vivo antileishmanial activity of Artemisia annua L. leaf powder and its potential usefulness in the treatment of uncomplicated cutaneous leishmaniasis in humans

• The efficacy of herbal medicines against Toxoplasma gondii during the last 3 decades: a systematic review

• A pilot randomized, placebo-controlled clinical trial to investigate the efficacy and safety of an extract of Artemisia annua administered over 12 weeks, for managing pain, stiffness, and functional limitation associated with osteoarthritis of the hip and knee

• Immunosuppressive effect of ethanol extract of Artemisia annua on specific antibody and cellular responses of mice against ovalbumin

• Anti-Tumour Effects of Polysaccharides Isolated from Artemisia Annua L by Inducing Cell Apoptosis and Immunomodulatory Anti-Hepatoma Effects of Polysaccharides

• Anti-Tumour Effects of Polysaccharides Isolated from Artemisia Annua L by Inducing Cell Apoptosis and Immunomodulatory Anti-Hepatoma Effects of Polysaccharides